What are your interests?
Select categories to help us recommend content for you.
Let's Go!
Close queue History
Play full episodes to fill your queue.
Fathom beta logo
   
Lifespan with Dr. David Sinclair

Lifespan with Dr. David Sinclair

9 Episodes • By Lifespan Communications LLC • www.lifespanpodcast.com
Join Dr. David Sinclair, Ph.D. in Lifespan, a popular health podcast that brings the cutting edge of aging and longevity science straight to you. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. This podcast is distin ...more
Health & Fitness
Lifespan with Dr. David Sinclair
Lifespan with Dr. David Sinclair
@lifespanwithdr.davidsinclair
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8
In the final episode of this season, Dr. David Sincl... more
Feb 23 2022 1h 9m
Chapter 1 3 mins
Introducing Episode Eight: The Future of Anti-aging Medicine
Chapter 2 2 mins
Thanking the Sponsors
Chapter 3 4 mins
Modern Healthcare, Disease Detection, and Circulating DNA
Chapter 4 9 mins
Wearable Monitors: A Dashboard for your Body
Chapter 5 3 mins
Types of Health Sensors
Chapter 6 5 mins
Big Data, Privacy, and Criminal Investigation
Chapter 7 6 mins
Cutting-edge Testing and Biological Age
Chapter 8 5 mins
Using Personalized Data to Inform your Diet
Chapter 9 3 mins
Optimizing Exercise and Activity-mimetics
Chapter 10 8 mins
Resetting the Aging Clock
Chapter 11 2 mins
Repeatable Age Reversal and Safety
Chapter 12 4 mins
Longer Life, Population Size, and Economics
Chapter 13 2 mins
Skillbatical
Chapter 14 1 min
Putting in the Work for Longevity
Chapter 15 3 mins
Thanking the Podcast Team and Wrapping Up Season One
Chapter 16 1 min
Options for Subscription and Support
Like
Clip
Share
Transcript
More
Play Full
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
The Science of Keeping the Brain Healthy | Episode 7
In this episode of the Lifespan podcast, Dr. David S... more
Feb 16 2022 1h 2m
Chapter 1 4 mins
Introducing Episode Seven: Aging of the Brain
Chapter 2 2 mins
Thanking the Sponsors
Chapter 3 1 min
Ex-differentiation as a Driver of Aging
Chapter 4 4 mins
The Brain Ages Slowly
Chapter 5 3 mins
Cognitive Function and Plasticity
Chapter 6 5 mins
Three Longevity Pathways: mTOR, AMPK, and Sirtuins
Chapter 7 5 mins
Plant-based Diets and B-vitamins
Chapter 8 4 mins
Homocysteine, Plaque, and Vasculature
Chapter 9 3 mins
Fatty Acids
Chapter 10 3 mins
Physical Activity
Chapter 11 6 mins
Metformin
Chapter 12 4 mins
NAD Boosters
Chapter 13 2 mins
Increasing Blood Flor
Chapter 14 4 mins
Sleep
Chapter 15 47 sec
Overall Message: Keep your Brain Healthy
Chapter 16 2 mins
Next Week’s Episode and the Future of Medicine
Chapter 17 46 sec
Options for Subscription for Support
Like
Clip
Share
Transcript
More
Play Full
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
The Science of Looking Younger, Longer | Episode 6
In Episode 6 of the Lifespan podcast, Dr. David Sinc... more
Feb 9 2022 1h 10m
Chapter 1 2 mins
Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair
Chapter 2 6 mins
Estrogen, Progesterone, and Menopause
Chapter 3 3 mins
Thanking the Sponsors
Chapter 4 5 mins
The Pinch Test, Epidermal Thinning, and Foot Ulcers
Chapter 5 4 mins
Skin and Biological Aging
Chapter 6 4 mins
Cellular Senescence, Ultraviolet Light, and Skin Aging
Chapter 7 5 mins
Collagen, Keratin, and Skin Health
Chapter 8 1 min
A Quick Aside about Nails
Chapter 9 2 mins
Autophagy and Retinoids
Chapter 10 4 mins
Resveratrol, NAD Boosters, and Hyaluronic Acid
Chapter 11 1 min
Botox, Skin Peels, and Microneedling
Chapter 12 2 mins
No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food
Chapter 13 4 mins
Hair Loss and Hair Graying
Chapter 14 5 mins
Topical Treatments, Pills, and Dihydrotestosterone
Chapter 15 2 mins
Frickin Laser Beams: Low-level Laser Therapy
Chapter 16 2 mins
Platelet-rich Plasma (PRP) Injections
Chapter 17 5 mins
Hair Aging, Stress, and Gray Hair Reversal
Chapter 18 1 min
Targeting Aging Upstream
Chapter 19 1 min
Today’s Takeaways
Chapter 20 51 sec
Subscription and Support Options
Like
Clip
Share
Transcript
More
Play Full
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) For Longevity | Episode 5
In this week’s episode of the Lifespan podcast, Dr. ... more
Feb 2 2022 59m
Chapter 1 2 mins
Kicking Off Episode Five: Interventions on the Cutting Edge
Chapter 2 2 mins
Expressing Gratitude to the Sponsors
Chapter 3 4 mins
Testosterone Replacement Therapy
Chapter 4 3 mins
Human Growth Hormone
Chapter 5 4 mins
Peptide Supplementation and Regenerative Signaling
Chapter 6 6 mins
MOTS-c, Humanin, and Other Peptides
Chapter 7 6 mins
Exosome Therapy
Chapter 8 6 mins
A Primer on Stem Cells and Yamanaka Factors
Chapter 9 3 mins
Stem Cell Aging and Cord Blood Banking
Chapter 10 1 min
The Therapeutic Potential of Stem Cells
Chapter 11 7 mins
Cellular Reprogramming
Chapter 12 5 mins
Resetting the Aging Clock
Chapter 13 1 min
The Future Looks Bright
Chapter 14 20 sec
Next Week’s Episode: External Aging
Chapter 15 38 sec
Subscription and Support Options
Like
Clip
Share
Transcript
More
Play Full
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4
In this week’s episode, Dr. David Sinclair and co-ho... more
Jan 26 2022 1h 10m
Chapter 1 2 mins
Kicking Off Episode Four: Longevity Molecules
Chapter 2 2 mins
Thanks the Sponsors
Chapter 3 1 min
An An Additional Boost Beyond Adversity Mimetics
Chapter 4 4 mins
Drugs vs. Supplements and Highlight Points
Chapter 5 1 min
Longevity Molecules Target the Survival Circuit
Chapter 6 1 min
NAD Boosters
Chapter 7 7 mins
Nicotinamide Riboside
Chapter 8 7 mins
Nicotinamide Mononucleotide
Chapter 9 3 mins
NAD Intravenous Drips
Chapter 10 54 sec
Bioavailability of NAD Boosters
Chapter 11 1 min
NAD and Cancer
Chapter 12 6 mins
Resveratrol
Chapter 13 41 sec
Red Wine and the French Paradox
Chapter 14 4 mins
Fisetin and Quercetin
Chapter 15 2 mins
Rapamycin and Rapalogs
Chapter 16 2 mins
Spermidine
Chapter 17 8 mins
Metformin
Chapter 18 2 mins
Berberine
Chapter 19 4 mins
Dr. Sinclair’s Protocol for Longevity Molecules
Chapter 20 1 min
Correction and clarification: At time point
Chapter 21 1 min
Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
Chapter 22 38 sec
Options for Subscription and Support
Like
Clip
Share
Transcript
More
Play Full
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3
In Episode 3 of the Lifespan Podcast, Dr. David Sinc... more
Jan 19 2022 1h 11m
Chapter 1 1 min
Introducing Episode 3: Exercise Hot Cold
Chapter 2 1 min
A Pernicisous Element Called Iron
Chapter 3 2 mins
A Quick Primer on Free Radicals
Chapter 4 1 min
Review of Dietary Takeaways
Chapter 5 2 mins
Sponsors
Chapter 6 3 mins
Biological Adversity & the Survival Circuit
Chapter 7 4 mins
Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) & Communicators (e.g., Insulin)
Chapter 8 2 mins
Get Off Your Butt
Chapter 9 1 min
Exercise Protects against Disease & Mortality
Chapter 10 1 min
Daily Step Count and Walking After Eating
Chapter 11 1 min
Exercise Activates AMPK and Creates More Mitochondria
Chapter 12 4 mins
Vigorous Exercise, Hypoxia, the Electron Transport Chain
Chapter 13 3 mins
Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation
Chapter 14 4 mins
The Epigenome and Biological Age are Impacted by Exercise
Chapter 15 47 sec
How to Measure your Biological Age
Chapter 16 1 min
Exercise Recommendations
Chapter 17 3 mins
Wearables and Individualized Health Tracking
Chapter 18 2 mins
The Importance of Weight Training
Chapter 19 1 min
Physical Activity & Senescent Cells
Chapter 20 1 min
Wrap-up & Takeaways
Chapter 21 7 mins
Hyperbaric Oxygen Therapy
Chapter 22 6 mins
Cold Therapy
Chapter 23 3 mins
Applying Heat
Chapter 24 1 min
Adversity Mimetics Produce Endorphins
Chapter 25 1 min
A Basic Protocol for Mimicking Adversity
Chapter 26 40 sec
Next Week: Molecules & Supplements
Chapter 27 52 sec
Subscription & Support
Like
Clip
Share
Transcript
More
Play Full
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
What to Eat & When to Eat for Longevity | Episode 2
In this episode, Dr. David Sinclair and co-host Matt... more
Jan 12 2022 1h 8m
Chapter 1 1 min
Introducing Ep. 2: What to Eat and When to Eat for Longevity
Chapter 2 3 mins
Sponsors
Chapter 3 3 mins
A Starting Place for Longevity: Eat Less Often
Chapter 4 1 min
Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy
Chapter 5 1 min
Dietary Longevity Strategies are Accessible (and Save Money)
Chapter 6 1 min
A Low Energy State Triggers a Genetic Pathway Involving Sirtuin Activation
Chapter 7 2 mins
NAD+ is Elevated by a Low Energy State
Chapter 8 2 mins
Fasting, mTOR, and AMPK
Chapter 9 3 mins
Data in Humans vs. Model Organisms
Chapter 10 2 mins
Evidence that Fasting is a Pro-longevity Intervention in Humans
Chapter 11 1 min
Evidence that Fasting can Attenuate Human Disease
Chapter 12 4 mins
Different Fasting Regimens
Chapter 13 3 mins
Focus on Time-restricted Feeding (≥ 16 Hours of Fasting)
Chapter 14 57 sec
Continuous Glucose Monitors
Chapter 15 2 mins
Genetics Influence How an Intervention Affects Aging
Chapter 16 1 min
A Trick for Fasting: Filling your Body with Fluids
Chapter 17 1 min
Intermittent Fasting with Adequate Nutrition (IFAN)
Chapter 18 5 mins
Things to Avoid: Excess Sugar and Protein
Chapter 19 2 mins
Branched Amino Acids, Red Meat, and mTOR
Chapter 20 3 mins
Plant-Based Diets Protect Against Aging
Chapter 21 2 mins
The Okinawa Diet and Blue Zones
Chapter 22 3 mins
Xenohormesis
Chapter 23 5 mins
Main Takeaways
Chapter 24 1 min
Obesity, Eating Habits, and Aging
Chapter 25 49 sec
Metabolic Winter Hypothesis
Chapter 26 38 sec
Preview for Ep. 3: Beneficial Stress
Chapter 27 47 sec
Subscription and Support
Like
Clip
Share
Transcript
More
Play Full
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
The Science Behind Why We Age | Episode 1
In this episode, Dr. David Sinclair and co-host Matt... more
Jan 5 2022 1h 2m
Chapter 1 3 mins
Introduction
Chapter 2 3 mins
Goal of the Lifespan Podcast
Chapter 3 3 mins
Acknowledgement of Sponsors
Chapter 4 5 mins
Aging is a Controllable Process that can be Slowed & Reversed
Chapter 5 5 mins
Organisms with Extreme Longevity
Chapter 6 7 sec
Genes that Regulate Aging: mTOR, AMPK, Sirtuins
Chapter 7 2 mins
mTOR & Rapamycin
Chapter 8 6 mins
AMP-activated protein kinase (AMPK) & Metformin
Chapter 9 4 mins
Sirtuin Proteins as Epigenetic Regulators of Aging
Chapter 10 7 mins
Ex-Differentiation
Chapter 11 5 mins
Measuring Aging Biological Age vs. Chronological Age
Chapter 12 1 min
No Law That Says We Have To Age
Chapter 13 3 mins
Episode Summary & Key Takeaways Why Do We Age?
Chapter 14 3 mins
Information Theory of Aging
Chapter 15 3 mins
Aging is a Medical Condition
Chapter 16 54 sec
Aging Myths Telomeres & Antioxidants
Chapter 17 41 sec
Options for Subscription and Support
Like
Clip
Share
Transcript
More
Play Full
mute button
Not AI Processed
Previews and search are not yet available for this episode.

Autoplay will start you at the beginning of the episode.
stars icon No captions Available
Welcome to Lifespan with Dr. David Sinclair
Welcome to Lifespan with Dr. David Sinclair. Dr. Dav... more
Dec 22 2021 1m
Like
Clip
Share
Transcript
More
Play Full